With its myriad hills and spectacular bay, San Francisco beguiles with natural beauty, vibrant neighborhoods, and contagious energy. Whether or not you’ve already visited the City by the Bay, it can overwhelm visitors with its offerings. Of course there are the well-trodden spots including Alamo Square, with its Painted Ladies; Fisherman’s Wharf and Pier 39; and twisting Lombard Street, the “crookedest street in the world.” But there’s much more to see and do, so we’ve selected the 25 top things every visitor should experience in San Francisco. Whether you're visiting for the first time or the fifth, these recommendations ensure that you’ll have a great trip.

Golden Gate Bridge

San Francisco's signature International Orange entryway is the city's majestic background, and about 10 million people a year head to the bridge for an up-close look. Walking the 1.7 miles to Marin County—inches from roaring traffic, steel shaking beneath your feet, and only a railing between you and the water 200 feet below—is much more than a superlative photo op (though it's that, too). Crossing the Golden Gate Bridge under your own power is exhilarating—a little scary, and definitely chilly. From the bridge's eastern-side walkway, the only side pedestrians are allowed on, you can take in the San Francisco skyline and the bay islands; look west for the wild hills of the Marin Headlands, the curving coast south to Lands End, and the Pacific Ocean.

Ferry Building

Foodies, rejoice! The historic Ferry Building is stuffed to the brim with all things tasty, including cafés, restaurants, a farmers' market, and merchants peddling everything from wine and olive oil to oysters and mushrooms. The building backs up to the bay, so the views are great—but they're even better from the decks of the departing ferries. San Franciscans flock to the street-level marketplace, stocking up on supplies from local favorites such as Acme Bread, Scharffen Berger Chocolate, Cowgirl Creamery, Blue Bottle Coffee, and Humphry Slocombe ice cream. Slanted Door, the city's beloved high-end Vietnamese restaurant, is here, along with highly regarded Bouli Bar. The seafood bar at Hog Island Oyster Company has fantastic bay view panoramas. On the plaza side, the outdoor tables at Gott's Roadside offer great people-watching with their famous burgers. On Saturday morning the plazas outside the building buzz with an upscale farmers' market where you can buy exotic sandwiches and other munchables.

Chinatown

If there’s one place in San Francisco that feels like a city unto itself, it’s Chinatown. Here, people dash between small neighborhood stores, their arms draped with plastic totes filled with groceries or souvenirs. Breathe in the scented air as you watch the nimble hands at Golden Gate Fortune Cookie Factory, then kick back with a cocktail at Li Po around the corner, rumored to be haunted by the ghost of an opium junkie still looking to score. At Tin How Temple, climb the narrow stairway to this space with hundreds of red lanterns, then step onto the tiny balcony and take in the alley scene below. And, of course, don’t skip a chance to have dim sum at Yank Sing.

Yerba Buena Gardens

There's not much south of Market Street that encourages lingering outdoors—or indeed walking at all—with this notable exception. These two blocks encompass the Center for the Arts, the Metreon, Moscone Convention Center, and the convention center's rooftop Children's Creativity Museum, but the gardens themselves are the everyday draw.Office workers escape to the green swath of the East Garden, the focal point of which is the memorial to Martin Luther King Jr. Powerful streams of water surge over large, jagged stone columns, mirroring the enduring force of King's words that are carved on the stone walls and on glass blocks behind the waterfall. Atop the Moscone Convention Center perch a few lures for kids. The historic Looff carousel twirls daily 10–5. South of the carousel is the Children's Creativity Museum, a high-tech, interactive arts-and-technology center geared to children ages 3–12. Kids can make Claymation videos, work in a computer lab, check out new games and apps, and perform and record music videos. Just outside, kids adore the excellent slides, including a 25-foot tube slide, at the play circle. Also part of the rooftop complex are gardens, an ice-skating rink, and a bowling alley.

Palace of Fine Arts

Perched on a swan-filled lagoon near the Marina's yacht harbor, this stirringly beautiful terra-cotta-color domed structure has an otherworldly quality about it. Built for the 1915 Panama-Pacific International Exposition and restored in 2008, the palace is a San Francisco architect's version of a Roman ruin, and it's been eliciting gasps for almost a century. The massive columns (each topped with four “weeping maidens”), great rotunda, and swan-filled lagoon have been used in countless fashion layouts, films, and wedding photo shoots. After admiring the lagoon, look across the street to the house at 3460 Baker St. If the maidens out front look familiar, they should—they're original casts of the “garland ladies” you can see in the Palace's colonnade.